一次意外中,威尔(杰克·尼科尔森 Jack Nicholson 饰)驾车撞倒了一只野狼,当他下车查看情况时,野狼咬伤了威尔。威尔并没有将受伤当成一回事,可自从事故发生以来,一些奇怪的变化开始出现在了威尔的身上,他的感官变得异常灵敏,脾气也愈发暴躁,所有的迹象都在显示,威尔似乎在慢慢的变成一只狼。 动物研究专家亚历齐亚斯(欧姆·普瑞 Om Puri 饰)证实了威尔的疑虑,他给了威尔一张护身符,它能够暂时帮助威尔控制自己的野性。威尔的妻子夏洛特(凯特·尼利甘 Kate Nelligan 饰)死了,死于喉咙被撕裂,威尔的朋友劳拉(米歇尔·菲佛 Michelle Pfeiffer 饰)为威尔做出了不在场证明,而当劳拉身陷险境之时,威尔也毫不犹豫的变成了狼人,出手相救。Worn down and out of luck, aging publisher Will Randall is at the end of his rope when a younger co-worker snatches both his job and wife out from under his nose. But after being bit by a wolf, Will suddenly finds himself energized, more competitive than ever, and possessed with amazingly heightened senses. Meanwhile, the beautiful daughter of his shrewd boss begins to fall for him - without realizing that the man she's begun to love is gradually turning into the creature by which he was bit.
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