亞當剛和女友分手,他的死黨柯瑞試圖幫助他走出情傷,因此常常帶他出去約會把妹。在這過程中,柯瑞提出是不是能實驗歸納出撩妹的必勝方程式,他們開始不斷嘗試以各種風格去追女生。此時辦公室來了一位新人史黛西,亞當和柯瑞都對她有意思,兩人的好友關係也因此受到挑戰。Four life-long friends who fail miserably in the dating world, set out to find the 'Perfect' way to pickup women. The lessons learned through their trials however turn out to be a lot more than they originally bargained for.