隔离区

电视台女主播安吉拉（珍妮弗•卡彭特 Jennifer Carpenter 饰）第一次出镜有些紧张，因为她要参加一个在洛杉矶某消防局与队员共度夜晚的节目。安吉拉性格热情开朗，所以逐渐融入了这个团队，她不但了解了每个人的个性，而且还迅速成为了他们的开心果。然而，突然接到911的报警电话，安吉拉随这群消防队员来到了出事地点。在这座阴森可怖的大楼里，不时传出女人凄厉的尖叫，当地警方已经封锁了大楼，消防队员试图疏散被困人群，却无意中身陷困境。在隔离的区域，一个女人不知感染什么病毒，残忍地伤害了许多人。眼看着消防队员惨遭不幸，自身难保的安吉拉被逼上了绝路……A television reporter and her cameraman are assigned to spend the night shift with a Los Angeles Fire Station. After a routine 911 call takes them to a small apartment building, they find police officers already on the scene in response to blood curdling screams coming from one of the apartment units. They soon learn that a woman living in the building has been infected by something unknown. After a few of the residents are viciously attacked, they try to escape with the news crew in tow, only to find that the CDC has quarantined the building. Phones, internet, televisions and cell phone access have been cut-off, and officials are not relaying information to those locked inside. When the quarantine is finally lifted, the only evidence of what took place is the news crew's videotape.