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杰西（德鲁·巴里摩尔 Drew Barrymore 饰）和米莉（托妮·科莱特 Toni Collette 饰）是从小玩到大的亲密好友，两人有着共同的童年回忆，彼此早已经成为了对方的一部分，密不可分。长大后，两人的友谊依然继续，米莉结了婚，有了两个可爱的孩子，生活在幸福和美满之中，这令杰西十分羡慕。 　　杰西也想和丈夫共同养育他们的孩子，只是一直不能如愿，在米莉的鼓励和陪伴之下，勇敢的杰西终于在经历了多次失败之后顺利怀孕，圆了自己做母亲的心愿，然而这时，米莉却被确诊患上了癌症。无法接受这一事实的米莉陷入了绝望之中，开始自暴自弃，杰西及时挺身而出，成为了好友最坚实的后盾。Milly and Jess have been best friends forever. They've shared everything since they were kids - secrets, clothes, laughs, substances, boyfriends... now they are trying to be grown-ups. Milly has a high-flying job and lives in a beautiful townhouse with husband Kit and their two kids. Jess is a town planner and she and her boyfriend Jago live on a bohemian houseboat on a London canal. Their friendship is as rock solid as ever. That is until Jess struggles to have a much longed-for baby and Milly finds out she has breast cancer. How do you share that?