李子威（王海祥 饰）是一名平凡的快递员，某日，在送快递的途中，李子威竟然被卷入了一桩命案之中，他所要送达的包裹亦成为了凶徒想要抢夺之物。在紧张刺激的你追我赶之中，李子威遭遇了车祸，醒来后发现自己竟然患上了“脸盲症”，这也就意味着，尽管见过凶手的真面目，但如今的他亦不能分辨此人究竟是谁。 在凶手的布局之下，李子威成为了警方重点怀疑的对象，就在这个节骨眼上，收件人楠叔致电李子威，声称拥有能够证明他清白的证据。就这样，李子威带着致命包裹踏上了前往丽江的旅途，途中结识了名为童欣（姚星彤 饰）的游客，两人在误打误撞之中产生了真挚的感情。Martial-arts legend Jackie Chan presents this pulse-pounding update to his own classic thriller. Finding himself at a murder scene, bike courier Li Ziwei tries to escape, but the culprits force him off a bridge. The amnesia from his head injuries means he can't recognize the faces of his enemies, who have framed him for the crime. Now, carrying the parcel that's his only clue, and with the help of sassy hitchhiker Tong Xin, Li Ziwei must outrun killers and cops while racing to clear his name of the mysterious murder.
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